September 23, 2023

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SCYNEXIS Announces $3 Million National Institutes of Health

SCYNEXIS Announces $3 Million National Institutes of Health
  • Researchers to review the probable of SCY-247 to combat Candida auris (C.auris), a multidrug-resistant pathogen named as an “urgent threat” by the Centers for Ailment Handle (CDC) and provided in the “critital priority group” on the World Health and fitness Firm (WHO) fungal priority pathogens listing (FPPL).
  • SCY-247 is a broad-spectrum, oral and IV antifungal beneath development by SCYNEXIS as a possible systemic therapeutic option for multiple drug-resistant pathogens.

JERSEY Town, N.J., Nov. 30, 2022 (Globe NEWSWIRE) — SCYNEXIS, Inc. (NASDAQ: SCYX), a biotechnology firm revolutionary impressive medicines to triumph over and avoid challenging-to-take care of and drug-resistant infections, right now introduced that scientists from Case Western Reserve College in Cleveland have been awarded a competitive investigation grant of much more than $3 million by the National Institutes of Wellness (NIH), to look into a next technology fungerp (SCY-247) created by SCYNEXIS as a opportunity therapy for Candida auris (C.auris), a multidrug-resistant yeast that causes critical and generally lethal infections.

The 5-calendar year grant from the Countrywide Institute of Allergy and Infectious Conditions of NIH will let the crew led by researchers at the Circumstance Western Reserve School of Drugs and College Hospitals Cleveland Healthcare Middle to assess this novel antifungal drug formulated by SCYNEXIS. The research team will be led by Mahmoud Ghannoum, Ph.D., professor of dermatology and pathology at the College of Medication and director of the Center for Professional medical Mycology at College Hospitals Medical Middle, Situation Western Reserve University, as principal investigator, and Thomas McCormick, Ph.D., an affiliate professor at the University of Drugs.

“It is thrilling to see the NIH fund this critical exploration to examine oral and IV SCY-247, just one of our patented triterpenoid antifungals, to concentrate on drug resistant C. auris, where by there is terrific want owing to minimal treatment options and the prospective to conserve life,” reported Marco Taglietti, M.D., President and Main Govt Officer of SCYNEXIS. “We congratulate Dr. Ghannoum on obtaining this grant and want to specific our gratitude for his ongoing dedication to people struggling from terrible and deadly fungal bacterial infections.”

C. auris has emerged in latest several years as a worldwide risk resulting in serious invasive infections with mortality as superior as 60 percent worldwide. The bulk of C. auris bacterial infections are reportedly resistant to fluconazole (FLU) with variable resistance to other members of the a few key courses of clinically accessible antifungals (azoles, polyenes, echinocandins). Some strains are resistant to all 3 antifungal courses, thereby restricting remedy options. C. auris has been labeled as an “urgent threat” by the Centers for Sickness Command (CDC). The Earth Wellness Group (WHO) a short while ago unveiled its very first at any time fungal priority pathogens checklist (FPPL), which consists of C. auris in the “critical precedence group.”

“There is an tremendous need to determine and create new modalities to handle bacterial infections prompted by the fungal pathogen Candida auris,” Dr. Ghannoum said. “Because C. auris colonizes the skin and functions as a nidus of infection, establishing a drug that can concurrently focus on skin and exhibit systemic efficacy will be remarkably modern and appealing. We will investigate whether SCY-247 is a feasible option for eradication of C. auris, and no matter whether this compound is successful from known resistant Candida species. The ability of the compound to address C. auris mind infection also will be assessed.”

About SCY-247

SCY-247 is a next generation fungerp, a triterpenoid course of antifungals, which represents the initial new class of antifungal compounds since 2001, and is beneath improvement as a probable systemic therapeutic possibility. The very first technology fungerp, ibrexafungerp, formerly recognised as SCY-078, [pronounced eye-BREX-ah-FUN-jerp] is an antifungal agent and the to start with agent of the novel class of structurally-distinctive glucan synthase inhibitors, triterpenoids. These agents merge the very well-established activity of glucan synthase inhibitors with the potential adaptability of having oral and intravenous (IV) formulations. Whilst ibrexafungerp is in late-phase improvement for various indications, together with lifetime-threatening fungal infections brought on primarily by Candida (such as C. auris) and Aspergillus species in hospitalized patients, SCY-247 is in early pre-IND development. SCY-247 has shown wide-spectrum antifungal exercise, in vitro and in vivo. SCYNEXIS anticipates that the U.S. Meals and Drug Administration (Food and drug administration) might grant SCY-247 Experienced Infectious Disorder Product or service (QIDP) and Rapid Track designations for the IV and oral formulations of SCY-247.

About SCYNEXIS

SCYNEXIS, Inc. (NASDAQ: SCYX) is a biotechnology organization groundbreaking modern medicines to assist millions of clients throughout the world triumph over and prevent tricky-to-deal with infections that are becoming increasingly drug-resistant. SCYNEXIS experts are creating the company’s lead asset, ibrexafungerp (formerly recognised as SCY-078), as a wide-spectrum, systemic antifungal for a number of fungal indications in equally the community and clinic options. SCYNEXIS has initiated the start of its 1st commercial product in the U.S., BREXAFEMME® (ibrexafungerp tablets). The U.S. Food and Drug Administration (Fda) authorized BREXAFEMME on June 1, 2021. SCYNEXIS submitted a supplemental New Drug Software (sNDA) to grow BREXAFEMME’s labelling to include things like the prevention of recurrent vulvovaginal candidiasis, and the Food and drug administration assigned a target PDUFA action date of November 30, 2022, for this more indicator. In addition, late-phase medical investigation of ibrexafungerp for the remedy of lifetime-threatening invasive fungal infections in hospitalized individuals is ongoing. For a lot more information, visit www.scynexis.com.

Contact:
Investor Relations
Irina Koffler
LifeSci Advisors
Tel: (646) 970-4681
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Media Relations
Debbie Etchison
SCYNEXIS
[email protected]