April 16, 2024

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TTUHSC El Paso scientist receives $2.6 million NIH grant for research on tuberculosis

TTUHSC El Paso scientist receives $2.6 million NIH grant for research on tuberculosis

For above a century, El Paso has very long been a sanctuary for people struggling from tuberculosis. It will before long be residence to groundbreaking exploration that helps prevent the debilitating disease. Texas Tech University Overall health Sciences Center El Paso infectious disease researcher Subramanian Dhandayuthapani, Ph.D., has been awarded a $2.6 million grant from the Countrywide Institutes of Wellness (NIH) to look into tuberculosis. The announcement was created forward of Entire world Tuberculosis Day, which is acknowledged every year on March 24.

Recognised as Dr. Pani on campus, the researcher’s five-year grant will discover building new vaccines to avoid tuberculosis, which has an effect on above 10 million folks around the world each individual year.


We’re very proud of Dr. Pani’s impressive accomplishment in becoming awarded the NIH R01 grant for his research on tuberculosis. This transformational grant will assist Dr. Pani and his team’s groundbreaking operate to enhance our knowledge of this infectious condition and create new, preventive vaccines for tuberculosis. The impact of this research will deal with wellness disparities in the underserved communities along the U.S.-Mexico border. We seem ahead to the progress his research will convey to our Borderplex local community and over and above.”


Richard Lange, M.D., M.B.A., TTUHSC El Paso President


The oldest and most widely sought-right after source of funding at the NIH, R01 grant programs are very competitive. The success price is as reduced as 10{33c86113bcc32821f63c6372852a0f501e07fff55ce3ce61b15b246c5f8c531c}, indicating that only a portion of applicants are effective in getting funding. As a testament to their worth, R01 grants normally set up a framework for best procedures or requirements of treatment in the wellness treatment occupation.

Tuberculosis, a hugely contagious disease caused by the bacterium Mycobacterium tuberculosis, mostly has an effect on the lungs. It is really a big public overall health issue, with the Planet Health and fitness Organization position it as the 13th leading induce of dying around the world and the leading trigger from a one infectious agent, with 10.6 million guys, ladies and kids stricken by the disorder. The emergence of drug-resistant tuberculosis strains has created the cure even more difficult, emphasizing the need to have for new drugs and therapies.

Tuberculosis is a severe general public wellbeing difficulty in El Paso County and in underserved communities together the U.S.-Mexico border. According to the Texas Section of State Health Providers, the incidence level of tuberculosis in El Paso County in 2020 was 2.7 situations for every 100,000 men and women, which is better than the condition typical of 1.9 conditions per 100,000 people today and the national common of 2.3 conditions per 100,000 individuals. The incidence amount of tuberculosis in Texas border counties was 2.8 cases for each 100,000 people today in 2020.

Doing the job in collaboration with Shrikanth Gadad, Ph.D., M.Sc., and Jessica Chacon, Ph.D., from TTUHSC El Paso and Chinnaswamy Jagannath, Ph.D., from Houston Methodist Research Institute, Houston, Dr. Pani’s do the job will leverage the newest developments in genomics, immunology and bioinformatics. Their focus is on the progress of improved new-era BCG (bacille Calmette-Guerin) vaccines. These serums comprise a weakened strain of the germs Mycobacterium bovis, which is relevant to the micro organism that induce human tuberculosis. When administered, the vaccine stimulates the immune program to understand and battle off similar micro organism in the foreseeable future, therefore furnishing protection in opposition to tuberculosis infection.

This is the second grant Dr. Pani has gained from the NIH for investigate in this spot. His first, a $492,258 grant from the NIH’s Nationwide Institute of Allergy and Infectious Illnesses, was awarded in 2021.

“Our research on tuberculosis vaccine progress is not only about obtaining new treatment plans but also strengthening health outcomes for clients all over the world,” stated Dr. Pani. “By identifying new targets and establishing new treatments, we can aid alleviate the burden of this condition. I’m honored to receive this NIH R01 grant, and enthusiastic about the possible effects our analysis could have on stopping this ailment.”

Dr. Pani is also a professor with TTUHSC El Paso’s Heart of Emphasis for Infectious Disorders inside the Department of Molecular and Translational Drugs. The Middle presents critical assets and knowledge to assist Dr. Pani’s operate, together with obtain to individual populations and highly developed research systems. In turn, his investigate also contributes to the center’s broader mission of addressing overall health disparities and improving upon overall health results for Hispanics in the area.

Collaboration among the the Facilities of Emphasis and with other institutions, local community organizations and stakeholders is crucial in addressing the elaborate wellbeing concerns confronted by Hispanics in the location. By operating with each other, scientists produce innovative methods to wellness care that make a important influence on the overall health of the group. By means of shared dedication to bettering overall health fairness and results, TTUHSC El Paso’s Centers of Emphasis demonstrate the electricity of collaboration in obtaining significant progress in addressing health and fitness disparities and strengthening the lives of individuals we provide.

The new vaccine has the probable to shield in opposition to other viral infections – it truly is developed to do the job in a nonspecific manner, which signifies it can help the immune system struggle off any viruses it encounters. This is an interesting advancement since it signifies the vaccine could have a broader effect on general public well being further than just tuberculosis avoidance.

Moreover, the vaccine has demonstrated opportunity in managing bladder cancer. Researchers have discovered the vaccine can encourage the immune process to acknowledge and attack cancer cells in the bladder. This is significant due to the fact bladder most cancers is the sixth most prevalent cancer in the U.S., and existing solutions can have debilitating aspect effects. If the vaccine is effective in clinical trials, it could provide a much more efficient and less invasive treatment solution for bladder cancer people.

The Borderplex location, which spans across West Texas, Southern New Mexico, and Northern Mexico, is household to a massive number of people who are at hazard of building tuberculosis because of to superior costs of poverty, migration and other elements. The funding of Dr. Pani’s exploration will not only advantage this community, but also contribute to the global effort and hard work to beat tuberculosis and enhance the overall health of populations all over the world.

Pupils attending TTUHSC El Paso will have the distinctive chance to achieve arms-on expertise by functioning on the task together with Dr. Pani and his team. When the grant is fully dedicated to investigate, college students from the Foster Faculty of Medicine and the Francis Graduate University of Biomedical Sciences will nevertheless have the opportunity to take part. The prospect to do the job on these an impactful job is a must have for pupils on the lookout to even more their education and learning and occupations in the health-related field.

About Texas Tech University Health Sciences Centre El Paso

TTUHSC El Paso is the only wellbeing sciences centre on the U.S.-Mexico border and serves 108 counties in West Texas that have been historically underserved. It can be a designated Title V Hispanic-Serving Establishment, making ready the future technology of well being treatment heroes, 48{33c86113bcc32821f63c6372852a0f501e07fff55ce3ce61b15b246c5f8c531c} of whom establish as Hispanic and are normally to start with-era pupils.

TTUHSC El Paso was set up to focus on the distinctive wellbeing treatment and educational wants of our Borderplex local community. In 2023, TTUHSC El Paso celebrates its 10th anniversary as an impartial university within the Texas Tech University System. In a decade, the college has graduated more than 2,000 medical professionals, nurses and researchers, and will soon insert dentists to its alumni.

Disclaimer: Analysis described in this media release was supported by the Nationwide Institute of Allergy and Infectious Health conditions of the Nationwide Institutes of Well being beneath Award Quantity R01AI175837. The articles is exclusively the responsibility of Texas Tech University Overall health Sciences Centre El Paso and does not automatically characterize the official sights of the National Institutes of Health and fitness.