December 18, 2024

Health Back

Professional Health Makers

Game-based health education to improve ART adherence of newly diagnosed young people with HIV: protocol for a stepped-wedge design randomized controlled trial | BMC Public Health

Game-based health education to improve ART adherence of newly diagnosed young people with HIV: protocol for a stepped-wedge design randomized controlled trial | BMC Public Health
  • Maswabi K, Ajibola G, Bennett K, Capparelli EV, Jean-Philippe P, Moyo S, Mohammed T, Batlang O, Sakoi M, Lockman S, Makhema J, Lichterfeld M, Kuritzkes DR, Hughes MD, Shapiro RL. Safety and Efficacy of Starting Antiretroviral Therapy in the First Week of Life. Clin Infect Dis. 2021;72(3):388–93. https://doi.org/10.1093/cid/ciaa028.

    Article 
    PubMed 

    Google Scholar
     

  • World Health Organization. Progress report 2016: prevent HIV, test and treat all: WHO support for country impact. 2016. https://apps.who.int/iris/handle/10665/251713. Accessed 27 Nov 2022.

  • Le PM, Nguyen PT, Nguyen HV, Bui DH, Vo SH, Nguyen NV, Nguyen TV, Tran AT, Le AD, Ha NM, Dao AT, Gilmour S. Adherence to highly active antiretroviral therapy among people living with HIV and associated high-risk behaviours and clinical characteristics: A cross-sectional survey in Vietnam. Int J STD AIDS. 2021;32(10):911–8. https://doi.org/10.1177/09564624211002405.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Agegnehu CD, Techane MA, Mersha AT, Atalell KA. Burden and Associated Factors of Virological Failure Among People Living with HIV in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. AIDS Behav. 2022;26(10):3327–36. https://doi.org/10.1007/s10461-022-03610-y.

    Article 
    PubMed 

    Google Scholar
     

  • Han WM, Law MG, Egger M, Wools-Kaloustian K, Moore R, McGowan C, Kumarasamy N, Desmonde S, Edmonds A, Davies MA, Yiannoutsos C, Althoff KN, Cortes CP, Mohamed TJ, Jaquet A, Anastos K, Euvrard J, Castelnuovo B, Salters K, Coelho LE, Ekouevi DK, Eley B, Diero L, Zaniewski E, Ford N, Sohn AH, Kariminia A, IeDEA collaboration. Global estimates of viral suppression in children and adolescents and adults on antiretroviral therapy adjusted for missing viral load measurements: a multiregional, retrospective cohort study in 31 countries. Lancet HIV. 2021;8(12):e766–75. https://doi.org/10.1016/S2352-3018(21)00265-4.

  • Chammartin F, Lodi S, Logan R, Ryom L, Mocroft A, Kirk O, d’Arminio Monforte A, Reiss P, Phillips A, El-Sadr W, Hatleberg CI, Pradier C, Bonnet F, Law M, De Wit S, Sabin C, Lundgren JD, Bucher HC, D:A:D Study Group. Risk for Non-AIDS-Defining and AIDS-Defining Cancer of Early Versus Delayed Initiation of Antiretroviral Therapy : A Multinational Prospective Cohort Study. Ann Intern Med. 2021;174(6):768–76. https://doi.org/10.7326/M20-5226.

  • Gan XM, Zhao DC, Zhao Y, Ma Y, Wu YS, Dou ZH. Progress on national antiretroviral treatment program during 2003–2021 in China. Chinese J AIDS STD. 2022;28(06):642–6. https://doi.org/10.13419/j.cnki.aids.2022.06.04.

    Article 

    Google Scholar
     

  • Zeng C, Li X, Qiao S, Yang X, Shen Z, Zhou Y. Anticipated stigma and medication adherence among people living with HIV: the mechanistic roles of medication support and ART self-efficacy. AIDS Care. 2020;32(8):1014–22. https://doi.org/10.1080/09540121.2020.1728213.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bae JW, Guyer W, Grimm K, Altice FL. Medication persistence in the treatment of HIV infection: a review of the literature and implications for future clinical care and research. AIDS. 2011;25(3):279–90. https://doi.org/10.1097/QAD.0b013e328340feb0.

    Article 
    PubMed 

    Google Scholar
     

  • Wang YY, Jin Y, Chen C, Zheng W, Wang SB, Ungvari GS, Ng CH, Zhang XD, Wang G, Xiang YT. Meta-analysis of adherence to highly active antiretroviral therapy in patients with HIV infection in China. AIDS Care. 2019;31(8):913–22. https://doi.org/10.1080/09540121.2018.1554238.

    Article 
    PubMed 

    Google Scholar
     

  • Kim SH, Gerver SM, Fidler S, Ward H. Adherence to antiretroviral therapy in adolescents living with HIV: systematic review and meta-analysis. AIDS. 2014;28(13):1945–56. https://doi.org/10.1097/QAD.0000000000000316.

    Article 
    CAS 
    PubMed 

    Google Scholar
     

  • Boerma RS, Boender TS, Bussink AP, Calis JC, Bertagnolio S, Rinke de Wit TF, Boele van Hensbroek M, Sigaloff KC. Suboptimal Viral Suppression Rates Among HIV-Infected Children in Low- and Middle-Income Countries: A Meta-analysis. Clin Infect Dis. 2016;63(12):1645–54.

    Article 
    PubMed 

    Google Scholar
     

  • Adejumo OA, Malee KM, Ryscavage P, Hunter SJ, Taiwo BO. Contemporary issues on the epidemiology and antiretroviral adherence of HIV-infected adolescents in sub-Saharan Africa: a narrative review. J Int AIDS Soc. 2015;18(1):20049. https://doi.org/10.7448/IAS.18.1.20049.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Brathwaite R, Ssewamala FM, Neilands TB, Okumu M, Mutumba M, Damulira C, Nabunya P, Kizito S, Sensoy Bahar O, Mellins CA, McKay MM. Predicting the individualized risk of poor adherence to ART medication among adolescents living with HIV in Uganda: the Suubi+Adherence study. J Int AIDS Soc. 2021;24(6):e25756. https://doi.org/10.1002/jia2.25756.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • China CDC. Infectious Disease Prevention and Control. 2022. http://www.nhc.gov.cn/jkj/s2907/new_list.shtml?tdsourcetag=s_pcqq_aiomsg. Accessed 21 Aug 2022.

  • Luanzhou Municipal People’s Hospital. 17-year-old high school student AIDS positive: a relationship with life, even once is enough to destroy you. 2022. http://www.lxrmyy.net/index.php/cms/shows/48/2466.html. Accessed 21 Aug 2022.

  • Joint United Nations Programme on HIV/AIDS. 2021 UNAIDS Global AIDS Update — Confronting inequalities, lessons for pandemic responses from 40 years of AIDS. 2021. https://www.unaids.org/en/resources/documents/2021/2021-global-aids-update. Accessed 21 Apr 2022.

  • Zhao Y, Wu Z, McGoogan JM, Sha Y, Zhao D, Ma Y, Brookmeyer R, Detels R, Montaner JSG. Nationwide Cohort Study of Antiretroviral Therapy Timing: Treatment Dropout and Virological Failure in China, 2011–2015. Clin Infect Dis. 2019;68(1):43–50. https://doi.org/10.1093/cid/ciy400.

    Article 
    PubMed 

    Google Scholar
     

  • Zhu J, Yousuf MA, Yang W, Zhu Q, Shen Z, Lan G, Chen Y, Chen H, Fan W, Xing H, Shao Y, Ruan Y, Li L. Mortality and Attrition Rates within the First Year of Antiretroviral Therapy Initiation among People Living with HIV in Guangxi, China: An Observational Cohort Study. Biomed Res Int. 2021;10(2021):6657112. https://doi.org/10.1155/2021/6657112.

    Article 
    CAS 

    Google Scholar
     

  • Xu MJ. The Characteristics of Health Information Seeking and Sexual Behaviors in Adolescents Living with HIV. Beijing: Chinese Center for Disease Control and Prevention; 2019.


    Google Scholar
     

  • Abiodun O, Ladi-Akinyemi B, Olu-Abiodun O, Sotunsa J, Bamidele F, Adepoju A, David N, Adekunle M, Ogunnubi A, Imhonopi G, Yinusa I, Erinle C, Soetan O, Arifalo G, Adeyanju O, Alawode O, Omodunbi T. A Single-Blind, Parallel Design RCT to Assess the Effectiveness of SMS Reminders in Improving ART Adherence Among Adolescents Living with HIV (STARTA Trial). J Adolesc Health. 2021;68(4):728–36. https://doi.org/10.1016/j.jadohealth.2020.11.016.

    Article 
    PubMed 

    Google Scholar
     

  • Ross J, Ingabire C, Umwiza F, Gasana J, Munyaneza A, Murenzi G, Nsanzimana S, Remera E, Akiyama MJ, Anastos KM, Adedimeji A. How early is too early? Challenges in ART initiation and engaging in HIV care under Treat All in Rwanda-A qualitative study. PLoS ONE. 2021;16(5):e0251645. https://doi.org/10.1371/journal.pone.0251645.

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Patel MS, Small DS, Harrison JD, Hilbert V, Fortunato MP, Oon AL, Rareshide CAL, Volpp KG. Effect of Behaviorally Designed Gamification With Social Incentives on Lifestyle Modification Among Adults With Uncontrolled Diabetes: A Randomized Clinical Trial. JAMA Netw Open. 2021;4(5):e2110255. https://doi.org/10.1001/jamanetworkopen.2021.10255.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Bellens A, Roelant E, Sabbe B, Peeters M, van Dam PA. A video-game based cognitive training for breast cancer survivors with cognitive impairment: A prospective randomized pilot trial. Breast. 2020;53:23–32. https://doi.org/10.1016/j.breast.2020.06.003.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Davis AJ, Parker HM, Gallagher R. Gamified applications for secondary prevention in patients with high cardiovascular disease risk: A systematic review of effectiveness and acceptability. J Clin Nurs. 2021;30(19–20):3001–10. https://doi.org/10.1111/jocn.15808.

    Article 
    PubMed 

    Google Scholar
     

  • Brown M, O’Neill N, van Woerden H, Eslambolchilar P, Jones M, John A. Gamification and Adherence to Web-Based Mental Health Interventions: A Systematic Review. JMIR Ment Health. 2016;3(3):e39. https://doi.org/10.2196/mental.5710.

  • LeGrand S, Muessig KE, McNulty T, Soni K, Knudtson K, Lemann A, Nwoko N, Hightow-Weidman LB. Epic Allies: Development of a Gaming App to Improve Antiretroviral Therapy Adherence Among Young HIV-Positive Men Who Have Sex With Men. JMIR Serious Games. 2016;4(1):e6. https://doi.org/10.2196/games.5687.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • LeGrand S, Muessig KE, Platt A, Soni K, Egger JR, Nwoko N, McNulty T, Hightow-Weidman LB. Epic Allies, a Gamified Mobile Phone App to Improve Engagement in Care, Antiretroviral Uptake, and Adherence Among Young Men Who Have Sex With Men and Young Transgender Women Who Have Sex With Men: Protocol for a Randomized Controlled Trial. JMIR Res Protoc. 2018;7(4):e94. https://doi.org/10.2196/resprot.8811.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Whiteley L, Mena L, Craker LK, Healy MG, Brown LK. Creating a Theoretically Grounded Gaming App to Increase Adherence to Pre-Exposure Prophylaxis: Lessons From the Development of the Viral Combat Mobile Phone Game. JMIR Serious Games. 2019;7(1):e11861. https://doi.org/10.2196/11861.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Casale M, Carlqvist A, Cluver L. Recent Interventions to Improve Retention in HIV Care and Adherence to Antiretroviral Treatment Among Adolescents and Youth: A Systematic Review. AIDS Patient Care STDS. 2019;33(6):237–52. https://doi.org/10.1089/apc.2018.0320.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mejia CM, Acland D, Buzdugan R, Grimball R, Natoli L, McGrath MR, Klausner JD, McCoy SI. An Intervention Using Gamification to Increase Human Immunodeficiency Virus and Sexually Transmitted Infection Screening Among Young Men Who Have Sex With Men in California: Rationale and Design of Stick To It. JMIR Res Protoc. 2017;6(7):e140. https://doi.org/10.2196/resprot.8064.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Montanaro E, Fiellin LE, Fakhouri T, Kyriakides TC, Duncan LR. Using Videogame Apps to Assess Gains in Adolescents’ Substance Use Knowledge: New Opportunities for Evaluating Intervention Exposure and Content Mastery. J Med Internet Res. 2015;17(10):e245. https://doi.org/10.2196/jmir.4377.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Gariepy AM, Hieftje K, Pendergrass T, Miller E, Dziura JD, Fiellin LE. Development and Feasibility Testing of a Videogame Intervention to Reduce High-Risk Sexual Behavior in Black and Hispanic Adolescents. Games Health J. 2018;7(6):393–400. https://doi.org/10.1089/g4h.2017.0142.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • DeSmet A, Shegog R, Van Ryckeghem D, Crombez G, De Bourdeaudhuij I. A Systematic Review and Meta-analysis of Interventions for Sexual Health Promotion Involving Serious Digital Games. Games Health J. 2015;4(2):78–90. https://doi.org/10.1089/g4h.2014.0110.

    Article 
    PubMed 

    Google Scholar
     

  • Tang J, Chen Y, Yu X, Ren J, Li M, Luo Y, Xie H, Wen J. AIDS fighter health defense: protocol for a randomized controlled trial to test a game-based intervention to improve adolescents’ AIDS prevention ability. BMC Infect Dis. 2021;21(1):469. https://doi.org/10.1186/s12879-021-06161-0.

  • Tang J, Zheng Y, Zhang D, Yu X, Ren J, Li M, Luo Y, Tian M, Chen Y. Evaluation of an AIDS Educational Mobile Game (AIDS Fighter· Health Defense) for Young Students to Improve AIDS-Related Knowledge, Stigma, and Attitude Linked to High-Risk Behaviors in China: Randomized Controlled Trial. JMIR Serious Games. 2022;10(1):e32400. https://doi.org/10.2196/32400.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Hemming K, Haines TP, Chilton PJ, Girling AJ, Lilford RJ. The stepped wedge cluster randomised trial: rationale, design, analysis, and reporting. BMJ. 2015;6(350):h391. https://doi.org/10.1136/bmj.h391.

    Article 

    Google Scholar
     

  • Health Commission of Sichuan Province. Epidemic situation of notifiable infectious diseases in Sichuan Province in 2021. http://wsjkw.sc.gov.cn/scwsjkw/rdts/2022/1/17/5b6824066f174d06b337209df13c2d6c.shtml (2021). Accessed 27 Nov 2022.

  • Hemming K, Taljaard M. Sample size calculations for stepped wedge and cluster randomised trials: a unified approach. J Clin Epidemiol. 2016;69:137–46. https://doi.org/10.1016/j.jclinepi.2015.08.015.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Anghel LA, Farcas AM, Oprean RN. An overview of the common methods used to measure treatment adherence. Med Pharm Rep. 2019;92(2):117–22. https://doi.org/10.15386/mpr-1201.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mannheimer S, Friedland G, Matts J, Child C, Chesney M. The consistency of adherence to antiretroviral therapy predicts biologic outcomes for human immunodeficiency virus-infected persons in clinical trials. Clin Infect Dis. 2002;34(8):1115–21. https://doi.org/10.1086/339074.

    Article 
    PubMed 

    Google Scholar
     

  • Karver TS, Donastorg Y, Perez M, Gomez H, Galai N, Barrington C, Celentano D, Kerrigan D. Assessing the Relationship Between HIV Quality of Care and Treatment Literacy on ART Adherence and Viral Suppression Among Female Sex Workers Living in the Dominican Republic. AIDS Behav. 2022;26(9):3056–67. https://doi.org/10.1007/s10461-022-03647-z.

    Article 
    PubMed 

    Google Scholar
     

  • Fu Y, Yang H, Yuan XQ, Gao MX, Chen YX, Sun YH, Zhou MG, Liu ZY, Chen YJ, Xu F, Huang Y, Li XM. Analysis on the awareness rate of knowledge about antiviral therapy for HIV/AID. Chinese Journal of AIDS & STD. 2016;22(11):867–70. https://doi.org/10.13419/j.cnki.aids.2016.11.07.

    Article 

    Google Scholar
     

  • Yu XL, Wen J, Tang J, Zhu J, Xie H, Chen YH. The Preliminary Development of Resilience Scale for People Living with HIV. Chinese J AIDS & STD. 2021;27(8):852–5. https://doi.org/10.13419/j.cnki.aids.2021.08.13.

    Article 
    CAS 

    Google Scholar
     

  • Li Z, Wang KR, Sheng Y. The reliability and validity of the Chinese version of Berger HIV stigma scale. Chinese Journal of Nursing. 2015 Jul;50(7):882-85. CNKI:SUN:ZHHL.0.2015-07-034

  • Kang R, Luo L, Chen H, Zhu Q, Liao L, Xing H, Zhu J, Shen Z, Lan G, Tang Z, Shao Y, Yang W, Ruan Y. Treatment outcomes of initial differential antiretroviral regimens among HIV patients in Southwest China: comparison from an observational cohort study. BMJ Open. 2019;9(3):e025666. https://doi.org/10.1136/bmjopen-2018-025666.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Du X, He Q, Yang T, Wang Y, Xu H, Hao C, Zhou K, Gu J, Hao Y. Intention to start ART after the launch of expanded treatment strategy among people living with HIV in China: a behavioral theory-based cross-sectional study. AIDS Care. 2020;32(9):1182–90. https://doi.org/10.1080/09540121.2019.1686601.

    Article 
    PubMed 

    Google Scholar
     

  • Horter S, Wringe A, Thabede Z, Dlamini V, Kerschberger B, Pasipamire M, Lukhele N, Rusch B, Seeley J. “Is it making any difference?” A qualitative study examining the treatment-taking experiences of asymptomatic people living with HIV in the context of Treat-all in Eswatini. J Int AIDS Soc. 2019;22(1):e25220. https://doi.org/10.1002/jia2.25220.

  • Hendrickson ZM, Naugle DA, Tibbels N, Dosso A, Van Lith ML, Mallalieu EC, Kamara D, DaillyAjavon P, Cisse A, SeifertAhanda K, Thaddeus S, Babalola S, Hoffmann CJ. “You Take Medications, You Live Normally”: The Role of Antiretroviral Therapy in Mitigating Men’s Perceived Threats of HIV in Côte d’Ivoire. AIDS Behav. 2019;23(9):2600–9. https://doi.org/10.1007/s10461-019-02614-5.

  • Chapman Lambert C, Westfall A, Modi R, Amico RK, Golin C, Keruly J, Quinlivan EB, Crane HM, Zinski A, Turan B, Turan JM, Mugavero MJ. HIV-related stigma, depression, and social support are associated with health-related quality of life among patients newly entering HIV care. AIDS Care. 2020;32(6):681–8. https://doi.org/10.1080/09540121.2019.1622635.

    Article 
    PubMed 

    Google Scholar
     

  • Patel MS, Small DS, Harrison JD, Fortunato MP, Oon AL, Rareshide CAL, Reh G, Szwartz G, Guszcza J, Steier D, Kalra P, Hilbert V. Effectiveness of Behaviorally Designed Gamification Interventions With Social Incentives for Increasing Physical Activity Among Overweight and Obese Adults Across the United States: The STEP UP Randomized Clinical Trial. JAMA Intern Med. 2019;179(12):1624–32. https://doi.org/10.1001/jamainternmed.2019.3505.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Mgbako O, Benoit E, Iyengar NS, Kuhner C, Brinker D, Duncan DT. “Like a ticking time bomb”: the persistence of trauma in the HIV diagnosis experience among black men who have sex with men in New York City. BMC Public Health. 2020;20(1):1247. https://doi.org/10.1186/s12889-020-09342-9.

  • Mwamba C, Beres LK, Topp SM, Mukamba N, Simbeza S, Sikombe K, Mody A, Geng E, Holmes CB, Kennedy CE, Sikazwe I, Denison JA, Bolton MC. I need time to start antiretroviral therapy’: understanding reasons for delayed ART initiation among people diagnosed with HIV in Lusaka, Zambia. Ann Med. 2022;54(1):830–6. https://doi.org/10.1080/07853890.2022.2051069.

  • Tao J, Vermund SH, Lu H, Ruan Y, Shepherd BE, Kipp AM, Amico KR, Zhang X, Shao Y, Qian HZ. Impact of Depression and Anxiety on Initiation of Antiretroviral Therapy Among Men Who Have Sex with Men with Newly Diagnosed HIV Infections in China. AIDS Patient Care STDS. 2017;31(2):96–104. https://doi.org/10.1089/apc.2016.0214.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Yang T, Yang X, Li L, Xu H, Fan L, Li Q, Fan X, Chen W, Du X, Hao C, Li J, Hao Y, Gu J. HIV diagnosis period influences ART initiation: findings from a prospective cohort study in China. AIDS Res Ther. 2021;18(1):59. https://doi.org/10.1186/s12981-021-00379-3.

    Article 
    PubMed 
    PubMed Central 

    Google Scholar
     

  • Seeley J, Bond V, Yang B, Floyd S, MacLeod D, Viljoen L, Phiri M, Simuyaba M, Hoddinott G, Shanaube K, Bwalya C, de Villiers L, Jennings K, Mwanza M, Schaap A, Dunbar R, Sabapathy K, Ayles H, Bock P, Hayes R, Fidler S, HPTN 071 (PopART). Understanding the Time Needed to Link to Care and Start ART in Seven HPTN 071 (PopART) Study Communities in Zambia and South Africa. AIDS Behav. 2019;23(4):929–46. https://doi.org/10.1007/s10461-018-2335-7.

  • Ryan RM, Deci EL. Self-determination theory and the facilitation of intrinsic motivation, social development, and well-being. Am Psychol. 2000;55(1):68–78. https://doi.org/10.1037//0003-066x.55.1.68.

    Article 
    CAS 
    PubMed 

    Google Scholar